DESPAIR

noun

1. Loss of hope; utter hopelessness; complete despondency.
2. That which causes despair.
3. That which is despaired of.

verb

1. To give up as beyond hope or expectation; to despair of.
2. To cause to despair.
3. (often with “of”) To be hopeless; to have no hope; to give up all hope or expectation.